Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

Schistosomiasis caused by a parasitic blood fluke of the genus Schistosoma afflicts over 200 million people worldwide. Schistosoma mansoni cathepsin B1 (SmCB1) is a gut-associated peptidase that digests host blood proteins as a source of nutrients. It is under investigation as a drug target. To furt...

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Detalhes bibliográficos
Main Authors: Jílková, Adéla, Řezáčová, Pavlína, Lepšík, Martin, Horn, Martin, Váchová, Jana, Fanfrlík, Jindřich, Brynda, Jiří, McKerrow, James H., Caffrey, Conor R., Mareš, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195637/
https://ncbi.nlm.nih.gov/pubmed/21832058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271304
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