Histone 3 Lysine 9 (H3K9) Methyltransferase Recruitment to the Interleukin-2 (IL-2) Promoter Is a Mechanism of Suppression of IL-2 Transcription by the Transforming Growth Factor-β-Smad Pathway

Suppression of IL-2 βproduction from T cells is an important process for the immune regulation by TGF-β. However, the mechanism by which this suppression occurs remains to be established. Here, we demonstrate that Smad2 and Smad3, two major TGF-β-downstream transcription factors, are redundantly ess...

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Detalhes bibliográficos
Main Authors: Wakabayashi, Yu, Tamiya, Taiga, Takada, Ichiro, Fukaya, Tomohiro, Sugiyama, Yuki, Inoue, Naoko, Kimura, Akihiro, Morita, Rimpei, Kashiwagi, Ikko, Takimoto, Tomohito, Nomura, Masatoshi, Yoshimura, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195630/
https://ncbi.nlm.nih.gov/pubmed/21862595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236794
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