SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

Regulatory T cells (T(reg) cells) maintain immune homeostasis by limiting inflammatory responses. SOCS1 (suppressor of cytokine signaling 1), a negative regulator of cytokine signaling, is necessary for the suppressor functions of T(reg) cells in vivo, yet detailed mechanisms remain to be clarified....

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Main Authors: Takahashi, Reiko, Nishimoto, Shuhei, Muto, Go, Sekiya, Takashi, Tamiya, Taiga, Kimura, Akihiro, Morita, Rimpei, Asakawa, Mayako, Chinen, Takatoshi, Yoshimura, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182063/
https://ncbi.nlm.nih.gov/pubmed/21893603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110428
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