Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

Mast cell degranulation is important in the pathogenesis of anaphylaxis and allergic disorders. Many animal venoms contain components that can induce mast cell degranulation, and this has been thought to contribute to the pathology and mortality caused by envenomation. However, we recently reported...

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Main Authors: Akahoshi, Mitsuteru, Song, Chang Ho, Piliponsky, Adrian M., Metz, Martin, Guzzetta, Andrew, Åbrink, Magnus, Schlenner, Susan M., Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Pejler, Gunnar, Tsai, Mindy, Galli, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195461/
https://ncbi.nlm.nih.gov/pubmed/21926462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46139
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