The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis

Mouse mast cell protease 4 (mMCP-4), the mouse counterpart of human mast cell chymase, is thought to have proinflammatory effects in innate or adaptive immune responses associated with mast cell activation. However, human chymase can degrade the proinflammatory cytokine TNF, a mediator that can be p...

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Hlavní autoři: Piliponsky, Adrian M., Chen, Ching-Cheng, Rios, Eon J., Treuting, Piper M., Lahiri, Asha, Abrink, Magnus, Pejler, Gunnar, Tsai, Mindy, Galli, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2012
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432424/
https://ncbi.nlm.nih.gov/pubmed/22901752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.05.013
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