Redirected Lysis of Human Melanoma Cells by a MCSP/CD3-bispecific BiTE Antibody that Engages Patient-derived T Cells

Melanoma-associated chondroitin sulfate proteoglycan (MCSP; also called HMW-MAA, CSPG4, NG2, MSK16, MCSPG, MEL-CSPG, or gp240) is a well characterized melanoma cell-surface antigen. In this study, a new bispecific T-cell engaging (BiTE) antibody that binds to MCSP and human CD3 (MCSP-BiTE) was teste...

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Main Authors: Torisu-Itakura, Hitoe, Schoellhammer, Hans F., Sim, Myung-Shin, Irie, Reiko F., Hausmann, Susanne, Raum, Tobias, Baeuerle, Patrick A., Morton, Donald L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195335/
https://ncbi.nlm.nih.gov/pubmed/21904216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182307fd8
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