In Vitro and In Vivo Activities of Novel, Semisynthetic Thiopeptide Inhibitors of Bacterial Elongation Factor Tu

Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like GE2270 A, target the essential bacterial protein elongation factor Tu (EF-Tu). Medicinal chemistry optimization of lead molecules led to the identification of preclinical development candidates 1...

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Detalhes bibliográficos
Main Authors: Leeds, J. A., LaMarche, M. J., Brewer, J. T., Bushell, S. M., Deng, G., Dewhurst, J. M., Dzink-Fox, J., Gangl, E., Jain, A., Lee, L., Lilly, M., Manni, K., Mullin, S., Neckermann, G., Osborne, C., Palestrant, D., Patane, M. A., Raimondi, A., Ranjitkar, S., Rann, E. M., Sachdeva, M., Shao, J., Tiamfook, S., Whitehead, L., Yu, D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195004/
https://ncbi.nlm.nih.gov/pubmed/21825297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00582-11
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