Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3

Varicella-zoster virus (VZV) infection of differentiated cells within the host and establishment of latency likely requires evasion of innate immunity and limits secretion of antiviral cytokines. Here we report that its immediate-early protein ORF61 antagonizes the beta interferon (IFN-β) pathway. V...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhu, Huifang, Zheng, Chunfu, Xing, Junji, Wang, Shuai, Li, Shuping, Lin, Rongtuan, Mossman, Karen L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2011
Gaiak:
Pathogenesis and Immunity
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194975/
https://ncbi.nlm.nih.gov/pubmed/21835786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05098-11
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