Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3

Varicella-zoster virus (VZV) infection of differentiated cells within the host and establishment of latency likely requires evasion of innate immunity and limits secretion of antiviral cytokines. Here we report that its immediate-early protein ORF61 antagonizes the beta interferon (IFN-β) pathway. V...

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Hlavní autoři: Zhu, Huifang, Zheng, Chunfu, Xing, Junji, Wang, Shuai, Li, Shuping, Lin, Rongtuan, Mossman, Karen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194975/
https://ncbi.nlm.nih.gov/pubmed/21835786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05098-11
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