Improved Knockout Methodology Reveals That Frog Virus 3 Mutants Lacking either the 18K Immediate-Early Gene or the Truncated vIF-2α Gene Are Defective for Replication and Growth In Vivo

To better assess the roles of frog virus 3 (FV3; genus Ranavirus, family Iridoviridae) genes in virulence and immune evasion, we have developed a reliable and efficient method to systematically knock out (KO) putative virulence genes by site-specific integration into the FV3 genome. Our approach uti...

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Detalhes bibliográficos
Main Authors: Chen, Guangchun, Ward, Brian M., Yu, Kwang H., Chinchar, V. Gregory, Robert, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194944/
https://ncbi.nlm.nih.gov/pubmed/21865381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05589-11
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