On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Bromovinyldeoxyuridine (BVdUrd) is a potent antiherpesvirus compound with low cytotoxicity. To gain an insight into its selectivity and mechanism of inhibition, we chemically synthesized the 5'-triphosphate of BVdUrd, BVdUTP, and tested its effect on the activities of DNA polymerases [DNA nucleotidy...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Allaudeen, H S, Kozarich, J W, Bertino, J R, De Clercq, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6265902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.5.2698
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