On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Bromovinyldeoxyuridine (BVdUrd) is a potent antiherpesvirus compound with low cytotoxicity. To gain an insight into its selectivity and mechanism of inhibition, we chemically synthesized the 5'-triphosphate of BVdUrd, BVdUTP, and tested its effect on the activities of DNA polymerases [DNA nucle...

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Bibliografiske detaljer
Main Authors: Allaudeen, H S, Kozarich, J W, Bertino, J R, De Clercq, E
Format: Artigo
Sprog:Inglês
Udgivet: 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC319424/
https://ncbi.nlm.nih.gov/pubmed/6265902
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