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A Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors

Human germ cell tumors are often metastatic, presumably due to distal site tumor growth by cancer stem cells. To determine whether cancer stem cells can be identified in a transplantation model of testicular germ cell tumor, we transplanted murine embryonic germ cells (EGCs) into the testis of adult...

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Hlavní autoři: Conway, Anne E., Lindgren, Anne, Galic, Zoran, Pyle, April D., Wu, Hong, Zack, Jerome A., Pelligrini, Matteo, Teitell, Michael A., Clark, Amander T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194037/
https://ncbi.nlm.nih.gov/pubmed/19224508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2008-0529
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