Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: Oxidation of Fumiquinazoline A to the Heptacyclic Hemiaminal Fumiquinazoline C by the Flavoenzyme Af12070 from Aspergillus fumigatus

The human pathogen Aspergillus fumigatus makes a series of fumiquinazoline (FQ) peptidyl alkaloids of increasing scaffold complexity using L-Trp, two equivalents of L-Ala, and the non-proteinogenic amino acid anthranilate as building blocks. The FQ gene cluster encodes two nonribosomal peptide synth...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ames, Brian D., Haynes, Stuart W., Gao, Xue, Evans, Bradley S, Kelleher, Neil L., Tang, Yi, Walsh, Christopher T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194008/
https://ncbi.nlm.nih.gov/pubmed/21899262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201302w
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares