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Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis

Aspergillus fumigatus Af293 is a known producer of quinazoline natural products including the antitumor fumiquinazolines, of which the simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid, tryptophan, and alanine. FQF is the proposed biological precurs...

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Detalhes bibliográficos
Principais autores: Ames, Brian D., Liu, Xinyu, Walsh, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006076/
https://ncbi.nlm.nih.gov/pubmed/20804163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1012029
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