Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus

Natural product discovery efforts have focused primarily on microbial biosynthetic gene clusters (BGCs) containing large multi-modular PKSs and NRPSs; however, sequencing of fungal genomes has revealed a vast number of BGCs containing smaller NRPS-like genes of unknown biosynthetic function. Using c...

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Publicat a:Nat Chem Biol
Autors principals: Baccile, Joshua A., Spraker, Joseph E., Le, Henry H., Brandenburger, Eileen, Gomez, Christian, Bok, Jin Woo, Macheleidt, Juliane, Brakhage, Axel A., Hoffmeister, Dirk, Keller, Nancy P., Schroeder, Frank C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5049701/
https://ncbi.nlm.nih.gov/pubmed/27065235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2061
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