Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling

A large fraction of ductal carcinoma in situ (DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade apoptosis, but the underlying mechanisms remain incompletely understood. We overexpressed...

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Detalhes bibliográficos
Main Authors: Pradeep, Chaluvally-Raghavan, Köstler, Wolfgang J., Lauriola, Mattia, Granit, Roy, Zhang, Fan, Jacob-Hirsch, Jasmine, Rechavi, Gideon, Nair, Hareesh B., Hennessy, Bryan T., Gonzalez-Angulo, Ana M., Tekmal, Rajeshwar R., Ben-Porath, Ittai, Mills, Gordon, Domany, Eytan, Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193899/
https://ncbi.nlm.nih.gov/pubmed/21743488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.279
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