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Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits
The Ca(2+) release-activated Ca(2+) (CRAC) channel pore is formed by Orai1 and gated by STIM1 after intracellular Ca(2+) store depletion. To resolve how many STIM1 molecules are required to open a CRAC channel, we fused different numbers of Orai1 subunits with functional two-tandem cytoplasmic domai...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193435/ https://ncbi.nlm.nih.gov/pubmed/20838418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.131 |
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