Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

The Ca(2+) release-activated Ca(2+) (CRAC) channel pore is formed by Orai1 and gated by STIM1 after intracellular Ca(2+) store depletion. To resolve how many STIM1 molecules are required to open a CRAC channel, we fused different numbers of Orai1 subunits with functional two-tandem cytoplasmic domai...

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Bibliografske podrobnosti
Main Authors: Li, Zhengzheng, Liu, Lin, Deng, Yongqiang, Ji, Wei, Du, Wen, Xu, Pingyong, Chen, Liangyi, Xu, Tao
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193435/
https://ncbi.nlm.nih.gov/pubmed/20838418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.131
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