Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis

Angiogenesis is stimulated by vascular endothelial growth factor (VEGF) and antagonized by type 1 interferons, including IFN-α/β. On engaging their respective receptors (VEGFR2 and IFNAR), both stimuli activate protein kinase D2 (PKD2) and type 1 IFNs require PKD2 activation and recruitment to IFNAR...

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Detalhes bibliográficos
Main Authors: Zheng, Hui, Qian, Juan, Carbone, Christopher J., Leu, N. Adrian, Baker, Darren P., Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193273/
https://ncbi.nlm.nih.gov/pubmed/21832278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-359745
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