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Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

The deleted in liver cancer 1 (DLC1) tumor suppressor gene, which is frequently inactivated in cancer, encodes a Rho-GAP (GTPase activating protein) focal adhesion protein whose negative regulation of Rho-GTPases is necessary but not sufficient for its full tumor suppressor activity. Here, we report...

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מידע ביבליוגרפי
Main Authors: Li, Guorong, Du, Xiaoli, Vass, William C., Papageorge, Alex G., Lowy, Douglas R., Qian, Xiaolan
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193248/
https://ncbi.nlm.nih.gov/pubmed/21969587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112122108
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