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Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer
To explain the large, opposite effects of urea and glycine betaine (GB) on stability of folded proteins and protein complexes, we quantify and interpret preferential interactions of urea with 45 model compounds displaying protein functional groups and compare with a previous analysis of GB. This inf...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193240/ https://ncbi.nlm.nih.gov/pubmed/21930943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109372108 |
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