Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling

Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that specifically inhibit oncoproteins such as BCR-ABL, c-Kit, HER2, PDGFR, and EGFR. Identifying additional gen...

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Autores principales: Scholer-Dahirel, Alix, Schlabach, Michael R., Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K., Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R., Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E., McLaughlin, Margaret E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193196/
https://ncbi.nlm.nih.gov/pubmed/21949247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104182108
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