A Conditional Gating Mechanism Assures the Integrity of the Molecular Force-Sensor Titin Kinase

As more and more recent investigations point out, force plays an important role in cellular regulation mechanisms. Biological responses to mechanical stress are often based on force-induced conformational changes of single molecules. The force sensor, titin kinase, is involved in a signaling complex...

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Bibliografiska uppgifter
Huvudupphovsmän: Stahl, Stefan W., Puchner, Elias M., Alexandrovich, Alexander, Gautel, Mathias, Gaub, Hermann E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2011
Ämnen:
Muscle, Motility, and Motor Proteins
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192984/
https://ncbi.nlm.nih.gov/pubmed/22004752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.09.027
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