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The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

Adeno-associated virus (AAV) provides a promising platform for clinical treatment of neurological disorders owing to its established efficacy and lack of apparent pathogenicity. To use viral vectors in treating neurological disease, however, transduction must occur under neuropathological conditions...

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Autors principals: Weinberg, MS, Blake, BL, Samulski, RJ, McCown, TJ
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192929/
https://ncbi.nlm.nih.gov/pubmed/21490684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.49
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