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Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

Fibroblast growth factor receptor 3 (FGFR3) is a major negative regulator of bone growth that inhibits the proliferation and differentiation of growth plate chondrocytes. Activating mutations of its c isoform cause dwarfism in humans; somatic mutations can drive oncogenic transformation in multiple...

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Autors principals: Degnin, Catherine R., Laederich, Melanie B., Horton, William A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192865/
https://ncbi.nlm.nih.gov/pubmed/21865593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-01-0080
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