Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain

BACKGROUND: Convection-enhanced delivery (CED) of adenoviruses offers the potential of widespread virus distribution in the brain. In CED, the volume of distribution (Vd) should be related to the volume of infusion (Vi) and not to dose, but when using adenoviruses contrasting results have been repor...

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Detalhes bibliográficos
Main Authors: Idema, Sander, Caretti, Viola, Lamfers, Martine L. M., van Beusechem, Victor W., Noske, David P., Vandertop, W. Peter, Dirven, Clemens M. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192704/
https://ncbi.nlm.nih.gov/pubmed/22022354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024396
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