Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice

BACKGROUND: We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into the F14.5L, J2R, and A56R loci of the VACV LIVP genome, respectively, resul...

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Hlavní autoři: Chen, Nanhai G, Yu, Yong A, Zhang, Qian, Szalay, Aladar A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192684/
https://ncbi.nlm.nih.gov/pubmed/21951588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-164
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