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Elevated Intact Proinsulin Levels Are Indicative of Beta-Cell Dysfunction, Insulin Resistance, and Cardiovascular Risk: Impact of the Antidiabetic Agent Pioglitazone
BACKGROUND: Insulin resistance (IR) and deterioration of beta-cell secretion are main features in the development of type 2 diabetes, which is reflected in increasing serum intact proinsulin levels in later disease stage. Introduction of stable assays that are able to distinguish between intact proi...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Diabetes Technology Society
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3192645/ https://ncbi.nlm.nih.gov/pubmed/21722594 |
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