Elevated Intact Proinsulin Levels During an Oral Glucose Challenge Indicate Progressive ß-Cell Dysfunction and May Be Predictive for Development of Type 2 Diabetes

BACKGROUND: Elevated fasting intact proinsulin is a biomarker of late-stage ß-cell-dysfunction associated with clinically relevant insulin resistance. In this pilot investigation, we explored the potential value of measuring intact proinsulin as a functional predictor of ß-cell exhaustion during an...

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Bibliografische gegevens
Gepubliceerd in:J Diabetes Sci Technol
Hoofdauteurs: Pfützner, Andreas, Hermanns, Iris, Ramljak, Sanja, Demircik, Filiz, Pfützner, Anke H., Kann, Peter H., Weber, Matthias M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: SAGE Publications 2015
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667304/
https://ncbi.nlm.nih.gov/pubmed/26420624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296815607862
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