Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin

Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this stu...

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Hlavní autoři: Jann, Naja J., Schmaler, Mathias, Kristian, Sascha A., Radek, Katherine A., Gallo, Richard L., Nizet, Victor, Peschel, Andreas, Landmann, Regine
Médium: Artigo
Jazyk:Inglês
Vydáno: The Society for Leukocyte Biology 2009
Témata:
Leukocytes: Tissue Interactions, Homeostasis and Host Defense
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192022/
https://ncbi.nlm.nih.gov/pubmed/19638500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0209053
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