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Role of Klotho in Aging, Phosphate Metabolism, and CKD

The klotho gene (KL) was first identified as a putative aging-suppressor gene that extended lifespan when over-expressed, and accelerated aging-like phenotypes when disrupted in mice. It encodes a single-pass transmembrane protein and is expressed predominantly in kidney, where it functions as an ob...

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Detalhes bibliográficos
Main Authors: John, George B., Cheng, Chung-Yi, Kuro-o, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191324/
https://ncbi.nlm.nih.gov/pubmed/21496980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.ajkd.2010.12.027
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