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ANALYSIS OF THE INTERACTION OF THE EG5 LOOP5 WITH THE NUCLEOTIDE SITE

Loop 5 (L5) is a conserved loop that projects from the α2-helix adjacent to the nucleotide site of all kinesin-family motors. L5 is critical to the function of the mitotic kinesin-5 family motors and is the binding site for several kinesin-5 inhibitors that are currently in clinical trials. Its conf...

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Autors principals: Harrington, Timothy D., Naber, Nariman, Larson, Adam G., Cooke, Roger, Rice, Sarah, Pate, Edward
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191284/
https://ncbi.nlm.nih.gov/pubmed/21872609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2011.08.017
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