Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling

Reactive oxygen species (ROS) induce matrix metalloproteinase (MMP) activity that mediates hypertrophy and cardiac remodeling. Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte remodeling. We tested the hypothesis that APN ame...

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Hlavní autoři: Essick, Eric E., Ouchi, Noriyuki, Wilson, Richard M., Ohashi, Koji, Ghobrial, Joanna, Shibata, Rei, Pimentel, David R., Sam, Flora
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2011
Témata:
Integrative Cardiovascular Physiology and Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191107/
https://ncbi.nlm.nih.gov/pubmed/21666115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2011
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