Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling

Reactive oxygen species (ROS) induce matrix metalloproteinase (MMP) activity that mediates hypertrophy and cardiac remodeling. Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte remodeling. We tested the hypothesis that APN ame...

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Main Authors: Essick, Eric E., Ouchi, Noriyuki, Wilson, Richard M., Ohashi, Koji, Ghobrial, Joanna, Shibata, Rei, Pimentel, David R., Sam, Flora
格式: Artigo
語言:Inglês
出版: American Physiological Society 2011
主題:
Integrative Cardiovascular Physiology and Pathophysiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191107/
https://ncbi.nlm.nih.gov/pubmed/21666115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2011
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