Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling

Reactive oxygen species (ROS) induce matrix metalloproteinase (MMP) activity that mediates hypertrophy and cardiac remodeling. Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte remodeling. We tested the hypothesis that APN ame...

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Bibliographic Details
Main Authors: Essick, Eric E., Ouchi, Noriyuki, Wilson, Richard M., Ohashi, Koji, Ghobrial, Joanna, Shibata, Rei, Pimentel, David R., Sam, Flora
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191107/
https://ncbi.nlm.nih.gov/pubmed/21666115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2011
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