Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling

Reactive oxygen species (ROS) induce matrix metalloproteinase (MMP) activity that mediates hypertrophy and cardiac remodeling. Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte remodeling. We tested the hypothesis that APN ame...

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Main Authors: Essick, Eric E., Ouchi, Noriyuki, Wilson, Richard M., Ohashi, Koji, Ghobrial, Joanna, Shibata, Rei, Pimentel, David R., Sam, Flora
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2011
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191107/
https://ncbi.nlm.nih.gov/pubmed/21666115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2011
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