Silencer of Death Domains (SODD) Inhibits Skeletal Muscle and Kidney Enriched Inositol 5-Phosphatase (SKIP) and Regulates Phosphoinositide 3-Kinase (PI3K)/Akt Signaling to the Actin Cytoskeleton

Phosphoinositide 3-kinase (PI3K) regulates cell polarity and migration by generating phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) at the leading edge of migrating cells. The serine-threonine protein kinase Akt binds to PI(3,4,5)P(3), resulting in its activation. Active Akt promotes spati...

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Detalhes bibliográficos
Main Authors: Rahman, Parvin, Huysmans, Richard D., Wiradjaja, Fenny, Gurung, Rajendra, Ooms, Lisa M., Sheffield, David A., Dyson, Jennifer M., Layton, Meredith J., Sriratana, Absorn, Takada, Hidetoshi, Tiganis, Tony, Mitchell, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191017/
https://ncbi.nlm.nih.gov/pubmed/21712384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.263103
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