Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation, synaptic plasticity, and morphology, and modest changes in BDNF levels results in complex behavioral phenotypes. BDNF levels and intracellular localization in neurons are regulated by multiple mechanisms, including use of d...

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Detalhes bibliográficos
Main Authors: Evans, Sarah Felice, Irmady, Krithi, Ostrow, Katya, Kim, Taeho, Nykjaer, Anders, Saftig, Paul, Blobel, Carl, Hempstead, Barbara L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190996/
https://ncbi.nlm.nih.gov/pubmed/21730062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219675
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