N-Methyl-N′-nitro-N-nitrosoguanidine (MNNG) Triggers MSH2 and Cdt2 Protein-dependent Degradation of the Cell Cycle and Mismatch Repair (MMR) Inhibitor Protein p21(Waf1/Cip1)

p21(Waf1/Cip1) protein levels respond to DNA damage; p21 is induced after ionizing radiation, but degraded after UV. p21 degradation after UV is necessary for optimal DNA repair, presumably because p21 inhibits nucleotide excision repair by blocking proliferating cell nuclear antigen (PCNA). Because...

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Autores principales: Jascur, Thomas, Fotedar, Rati, Greene, Serena, Hotchkiss, Erin, Boland, C. Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190993/
https://ncbi.nlm.nih.gov/pubmed/21725088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221341
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