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MMR/c-Abl-dependent activation of ING2/p73α signaling regulates the cell death response to N-methyl-N’-nitro-N-nitrosoguanidine
Agents inducing O(6)-methylguanine (O(6)MeG) in DNA such as N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) are cytotoxic and a deficiency in mismatch repair (MMR) results in lack of sensitivity to this genotoxin (termed alkylation tolerance). Here, we show that ING2, a member of the inhibitor of growth...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773549/ https://ncbi.nlm.nih.gov/pubmed/19766113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.09.010 |
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