Identification of a Negative Regulatory Region for the Exchange Activity and Characterization of T332I Mutant of Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10)

The T332I mutation in Rho guanine nucleotide exchange factor 10 (ARHGEF10) was previously found in persons with slowed nerve conduction velocities and thin myelination of peripheral nerves. However, the molecular and cellular basis of the T332I mutant is not understood. Here, we show that ARHGEF10 h...

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Bibliografiske detaljer
Main Authors: Chaya, Taro, Shibata, Satoshi, Tokuhara, Yasunori, Yamaguchi, Wataru, Matsumoto, Hiroshi, Kawahara, Ichiro, Kogo, Mikihiko, Ohoka, Yoshiharu, Inagaki, Shinobu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190991/
https://ncbi.nlm.nih.gov/pubmed/21719701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236810
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