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Truncation, Randomization, and Selection: GENERATION OF A REDUCED LENGTH c-Jun ANTAGONIST THAT RETAINS HIGH INTERACTION STABILITY

The DNA binding activity of the transcriptional regulator activator protein-1 shows considerable promise as a target in cancer therapy. A number of different strategies have been employed to inhibit the function of this protein with promise having been demonstrated both in vitro and in vivo. Peptide...

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Detalhes bibliográficos
Main Authors: Crooks, Richard O., Rao, Tara, Mason, Jody M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190987/
https://ncbi.nlm.nih.gov/pubmed/21697091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221267
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