Non-core Region Modulates Interleukin-11 Signaling Activity: GENERATION OF AGONIST AND ANTAGONIST VARIANTS

Human interleukin-11 (hIL-11) is a pleiotropic cytokine administered to patients with low platelet counts. From a structural point of view hIL-11 belongs to the long-helix cytokine superfamily, which is characterized by a conserved core motif consisting of four α-helices. We have investigated the re...

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Autori principali: Yanaka(谷, Saeko, 中冴子), Sano(佐, Emiko, 野恵海子), Naruse(成, Norio, 瀬紀男), Miura(三, Kin-ichiro, 浦謹一郎), Futatsumori-Sugai(二, Mutsumi, ツ森ー菅井睦美), Caaveiro, Jose M. M., Tsumoto(津, Kouhei, 本浩平)
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048695/
https://ncbi.nlm.nih.gov/pubmed/21138838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152561
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