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A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity

Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans...

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Detalhes bibliográficos
Main Authors: Roosild, Tarmo P., Castronovo, Samantha, Villoso, Adelbert, Ziemba, Amy, Pizzorno, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190963/
https://ncbi.nlm.nih.gov/pubmed/21855639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.08.002
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