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A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190963/ https://ncbi.nlm.nih.gov/pubmed/21855639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.08.002 |
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