WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) plays an important role in the proliferation of tumor cells and the lifespan of Caenorhabditis elegans. However, the role of WWP1 in cellular senescence is still unknown. Here, we show that the expression patterns of p27(Kip1) and WWP1 are in...

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Bibliographic Details
Main Authors: Cao, Xiaoxiao, Xue, Lixiang, Han, Limin, Ma, Liwei, Chen, Tianda, Tong, Tanjun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190933/
https://ncbi.nlm.nih.gov/pubmed/21795702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225565
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