Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein: IMPLICATIONS FOR NEURONAL CELL DEATH IN PARKINSON DISEASE

Parkinson disease (PD), a prevalent neurodegenerative motor disorder, is characterized by the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched Lewy body inclusions in the substantia nigra of the midbrain. Although the etiology of PD remains incompletely understo...

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Autors principals: Chew, Katherine C. M., Ang, Eng-Tat, Tai, Yee Kit, Tsang, Fai, Lo, Shun Qiang, Ong, Elijah, Ong, Wei-Yi, Shen, Han-Ming, Lim, Kah-Leong, Dawson, Valina L., Dawson, Ted M., Soong, Tuck Wah
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190914/
https://ncbi.nlm.nih.gov/pubmed/21795716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268409
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