Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

7-Ketocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic in liver cells. Multiple origins of this compound have been identified, with cholesterol being the presumed precursor. Although routes for formation of the 7-keto compound from cholesterol have...

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Bibliographic Details
Main Authors: Shinkyo, Raku, Xu, Libin, Tallman, Keri A., Cheng, Qian, Porter, Ned A., Guengerich, F. Peter
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190903/
https://ncbi.nlm.nih.gov/pubmed/21813643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282434
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