The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions

Recently, we identified extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist. However, the receptor selectivity and molecular basis of the CXCR4 agonist activity of ubiquitin are unknown, and functional consequences of CXCR4 activation with ubiquitin are poorly defined. H...

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Hauptverfasser: Saini, Vikas, Staren, Daniel M., Ziarek, Joshua J., Nashaat, Zayd N., Campbell, Edward M., Volkman, Brian F., Marchese, Adriano, Majetschak, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190899/
https://ncbi.nlm.nih.gov/pubmed/21757744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.233742
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