Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1α suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor α (Rara)-dependent transcription and cell proliferation. However, Rara targets regulated by Trim24 remain unknown. We report that th...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Tisserand, Johan, Khetchoumian, Konstantin, Thibault, Christelle, Dembélé, Doulaye, Chambon, Pierre, Losson, Régine
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2011
الموضوعات:
Molecular Bases of Disease
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190892/
https://ncbi.nlm.nih.gov/pubmed/21768647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225680
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