Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α (RARα) and oncogenic RARα fusion proteins

Analyzing the pathways by which retinoic acid (RA) induces promyelocytic leukemia/retinoic acid receptor α (PML/RARα) catabolism in acute promyelocytic leukemia (APL), we found that, in addition to caspase-mediated PML/RARα cleavage, RA triggers degradation of both PML/RARα and RARα. Similarly, in n...

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Autors principals: Zhu, Jun, Gianni, Maurizio, Kopf, Eliezer, Honoré, Nicole, Chelbi-Alix, Mounira, Koken, Marcel, Quignon, Frédérique, Rochette-Egly, Cécile, de Thé, Hugues
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24729/
https://ncbi.nlm.nih.gov/pubmed/10611294
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