Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1α suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor α (Rara)-dependent transcription and cell proliferation. However, Rara targets regulated by Trim24 remain unknown. We report that th...

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Hlavní autoři: Tisserand, Johan, Khetchoumian, Konstantin, Thibault, Christelle, Dembélé, Doulaye, Chambon, Pierre, Losson, Régine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190892/
https://ncbi.nlm.nih.gov/pubmed/21768647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225680
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